Agrivet Life Science

Introduction

Agrivet Life Sciences, is a division of Agrivet Research & Advisory Pvt., Ltd. dedicated to partnering support in research projects of organizations and institutions across diverse sectors including pharmaceuticals, biotechnology, cancer research, medical devices, biomedical technologies, nutraceuticals, cosmeceuticals, food processing, xenobiotic and agrochemical testing.

Our team of scientists has deep expertise in zebrafish biology and experimental techniques. We ensure high experimental throughput and data reliability. This enables Agrivet Life Sciences to offer a comprehensive range of services, including chemical screening, toxicity testing, genetic studies, disease modelling, target validation, drug efficacy screening, chemical safety assessments and beyond.

By using zebrafish larvae, we support the principles of the 3Rs (Replacement, Reduction, Refinement) in animal research. As a registered research organization with CCSEA, we believe and practice the principles of the 3Rs in animal research. We aim to empower innovators striving to develop life-enhancing products and advance health solutions.

With an unwavering commitment to innovation, collaboration, and sustainability, Agrivet Life Sciences is poised to make a lasting impact in the industry. Together, we can drive progress and improve quality of life for all.

Our Commitment to Ethical Research

As a registered research organization with CCSEA, we are committed to upholding high standards of animal welfare without compromising research quality.

Research & Innovation

Why Zebrafish?

Zebrafish larvae offer a compelling alternative to traditional animal models, especially in areas like drug screening and toxicology. Being vertebrates, they effectively replace the need for larger, more complex animals in many studies. Their small size and rapid development allow for the early assessment of compound effects, significantly reducing the number of animals needed in later stages of research. Their transparent embryos enable real-time observation of various physiological processes in a live, intact organism, refining research practices by minimizing distress and aligning with humane standards.

Additionally, zebrafish share essential organs and genetic pathways with humans. They are cost-effective, have shorter life cycles, and require fewer resources, making them ideal for rapid and efficient scientific discovery. Also, zebrafish larvae are subject to fewer ethical restrictions than mammals, providing more flexibility in early-stage research.

Our Service Offering

Zebrafish-Based Research Services

1. General Toxicity Assays:

General toxicity tests assess the potential risk of chemicals in an organism and evaluate its environmental risk, primarily through acute and chronic toxicity evaluations. Acute toxicity test is used to characterise hazardous chemical in shorter duration (usually 96 hours), measuring the concentration that kills 50% of the initial population, while chronic toxicity tests examine the effects on hatching, growth, and survival to establish No Observed Effect Concentration (NOEC) and Lowest Observed Effect Concentration (LOEC). Here these tests typically involve zebrafish, a freshwater species, and use a geometric series of at least five or more concentrations.

Agrivet Life Sciences offers the following toxicity tests:

• OECD Fish Tests No. 203: Fish, Acute Toxicity Test
• OECD Fish Tests No. 204: Fish, Prolonged Toxicity Test: 14-Day Study
• OECD Fish Tests No. 210: Fish, Early-life Stage Toxicity Test
• OECD Fish Tests No. 212: Fish, Short-term Toxicity Test on Embryo and Sac-Fry Stages
• OECD Fish Tests No. 215: Fish, Juvenile Growth Test
• OECD Fish Tests No. 230: 21-day Fish Assay: A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition
• OECD Fish Tests No. 229: Fish Short Term Reproduction Assay
• OECD Fish Tests No. 234: Fish Sexual Development Test
• OECD Fish Tests No. 236: Fish Embryo Acute Toxicity (FET) Test
• OECD Fish Tests No. 305: Bioconcentration: Flow-through Fish Test
• Developmental Teratogeny

2. Organ-Specific Toxicity Assays:

A wide range of compounds, including drugs, fertilizers, and natural pollutants, can cause specific damage to targeted organs. To facilitate the study of such chemicals, we offer organ-specific toxicity assays, including liver (HepatoTox), heart (CardioTox), central nervous system (NeuroTox), muscle, and kidney (Nephrotoxicity) assays.

3. Genetic Manipulation and CRISPR Services:

Agrivet Life Sciences offer customized genetic manipulation and CRISPR gene-editing services tailored to the needs of academia and the pharmaceutical industry, supporting research in drug discovery and target validation.

4. Disease Models:

We specialize in developing zebrafish disease models using chemical and genetic approaches to study genetic or metabolic disorders, disease progression, and preclinical stages relevant to drug discovery and target identification.

Industries We Serve

• Pharmaceuticals: Early-stage safety and efficacy testing.
• Biotechnology: Genetic and disease model testing.
• Food and Cosmetics: Testing for toxicity and safety.
• Agrochemicals: Efficient screening of high-risk compounds.
• Academic and research institutes: Facilitate their research work and screening of novel compounds.

Quality & Compliance

We maintain the highest standards of Quality Assurance (QA) to ensure that our zebrafish-based research is accurate, reliable, and reproducible—critical for supporting drug discovery and disease modeling. Our rigorous QA protocols involve precise dosages, well-calibrated instruments, validated genetic tools, and strict adherence to standardized procedures, from reagent selection to environmental documentation.